All products Antibodies Rabbit anti-CCND1 polyclonal antibody - middle region

Rabbit anti-CCND1 polyclonal antibody - middle region

Catalog Number：OM105163

  • 0.2-1 ug/ml
    ELISA Titer: 1:62500
    Positive Control: 721_B cell lysate

Product Profile

Product Name Rabbit anti-CCND1 polyclonal antibody - middle region
Antibody Type Primary Antibodies
Immunogen 
The immunogen for anti-CCND1 antibody: synthetic peptide directed towards the middle region of human CCND1

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity

BovineDogHorseHuman
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol CCND1
Gene Synonyms
BCL1
D11S287E
PRAD1
U21B31
Gene Full Name Cyclin D1
Gene Summary
CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alternative Names
BCL1
D11S287E
PRAD1
U21B31
Molecular Weight(MW) 34kDa
Sequence 295 amino acids

Database Links

Entrez Gene 595
SwissProt ID P24385
Protein Accession NP_444284

Application

  • Western blot

    0.2-1 ug/ml
    ELISA Titer: 1:62500
    Positive Control: 721_B cell lysate

Application Notes
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM105163
  • Price: $336.00
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