All products Antibodies TERF2 Antibody

TERF2 Antibody

Catalog Number：OM293103

  • Western blot analysis of TERF2 in 293 cell lysate with TERF2 antibody at 1 μg/ml.

  • Immunohistochemistry of TERF2 in human kidney tissue with TERF2 antibody at 5 μg/mL.

Product Profile

Product Name TERF2 Antibody
Antibody Type Primary Antibodies
Product description 
The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1). TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2). TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3). TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5).1) Broccoli D, Smogorzewska A, Chong L, et al. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat. Genet. 1997; 17:231-5.
Immunogen 
TERF2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TERF2. The immunogen is located within the first 50 amino acids of TERF2.

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

ELISAIHC-PWB
TERF2 antibody can be used for detection of TERF2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL.:
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol TERF2
Alternative Names
TERF2 Antibody: TRF2
TRBF2
TRF2
Telomeric repeat-binding factor 2
TTAGGG repeat-binding factor 2
Molecular Weight(MW) Predicted: 60 kDa Observed: 69 kDa
Sequence Similarities 2) Cat. No. 10-401 - Human Kidney Tissue Slide
Tissue Specificity TERF2 antibody is human specific.

Database Links

Entrez Gene 7014
Protein Accession NP_005643

Application

  • Application

    Western blot analysis of TERF2 in 293 cell lysate with TERF2 antibody at 1 μg/ml.

  • Application

    Immunohistochemistry of TERF2 in human kidney tissue with TERF2 antibody at 5 μg/mL.

Positive Control 1) Cat. No. 1210 - HEK293 Cell Lysate
Application Notes
TERF2 antibody can be used for detection of TERF2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL.:

Additional Information

Form Liquid
Storage Instructions TERF2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Storage Buffer TERF2 Antibody is supplied in PBS containing 0.02% sodium azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM293103
  • Price: $336.00
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