Application
PAX6 Antibody (Cat. #AM1871b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PAX6 antibody detected the PAX6 protein (arrow).| Product Name | PAX6 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PAX6; AN2; Paired box protein Pax-6; Aniridia type II protein; Oculorhombin |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 193CT15.2.2 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100~1000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | AN2 |
|---|---|
| Alternative Names | PAX6 AN2 Paired box protein Pax-6 Aniridia type II protein Oculorhombin |
| Molecular Weight(MW) | 46683 Da |
| Function | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes |
| Tissue Specificity | Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form |
| Cellular Localization | Nucleus. |
| Entrez Gene | 5080 |
|---|---|
| Nucleotide Accession | NP_001121084.1 NP_001595.2 |
Application
PAX6 Antibody (Cat. #AM1871b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PAX6 antibody detected the PAX6 protein (arrow).| Application Notes | WB:1:100~1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
