Mouse monoclonal antibody [2E2] to ACEThis gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
DCP ACE1 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 DCP1 ICH MVCD3 CD143
Target
ACE
Molecular Weight(MW)
somatic form: 170kDa; germinal form: 90kDa (note)
Tissue Specificity
This antibody recognizes denatured ACE.
Application Notes
Western Blotting: 1/50 - 1/100:
Additional Information
Form
Liquid
Storage Instructions
Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.