| Product Name | beta Amyloid (1-40) antibody [4H308] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [4H308] to beta Amyloid (1-40)The cerebral and vascular plaques associated with Alzheimer's disease (AD) are mainly composed of amyloid beta peptides (Ab). Ab is derived from cleavage of the amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. Ab [1-40], Ab [1-42], and Ab [1-43] peptides result from cleavage of APP after residues 40, 42, and 43, respectively. The cleavage takes place by gamma secretase during the last APP processing step. Ab [1-40], [1-42] and [1-43] peptides are major constituents of the plaques and tangles that occur in AD. Ab antibodies and peptides have been developed as tools for elucidating the biology of AD. |
| Immunogen | Synthetic peptide conjugated to KLH, corresponding to amino acids 34-40 of Human beta Amyloid 1-40. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Clone Number | 4H308 |
| Host Species | Mouse |
| Tested Applications | IHC-PWB |
| WB: 1/1000. Detects a band of approximately 4.5 kDa (predicted molecular weight: 4.5 kDa). IHC-P: 1/250 detects amyloid b in human brain sections. Optimal dilutions/concentrations should be determined by the end user. | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | AD1, APP, ABETA, CTFgamma, APPI, 351, ABPP, CVAP, beta Amyloid, PN2, 104760, P05067, AAA |
|---|---|
| Target | beta Amyloid (1-40) |
| Tissue Specificity | Recognizes amyloid bx-40 polypeptide, Mr 4.5kD. At dilution of 1/1000 detects 1microgram of synthetic amyloid b1-40 polypeptide, but not amyloid b1-42 and 1-43. |
| Cellular Localization | Type I membrane protein. |
| Application Notes | WB: 1/1000. Detects a band of approximately 4.5 kDa (predicted molecular weight: 4.5 kDa). IHC-P: 1/250 detects amyloid b in human brain sections. Optimal dilutions/concentrations should be determined by the end user. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.05% Sodium Azide. Constituents: Ascites |
