| Product Name | beta Amyloid antibody [2C8] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [2C8] to beta AmyloidThe cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimer's disease. |
| Immunogen | Synthetic peptide, corresponding to amino acids 1-16 of beta Amyloid. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 2C8 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| IHC: Use at a concentration of 10 µg/ml. WB: Use at a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 4-5 kDa. Optimal dilutions/concentrations should be determined by the end user. | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein A |
| Gene Synonyms | AD1, APP, ABETA, CTFgamma, APPI, 351, ABPP, CVAP, beta Amyloid, PN2, 104760, P05067, AAA |
|---|---|
| Target | beta Amyloid |
| Tissue Specificity | This antibody reacts with synthetic beta amyloid [A beta (40) and A beta (42)] in Western blots. This antibody does not react with recombinant beta amyloid (AA 601-744). Thus this antibody recognizes the N-termini of A beta (40) and A beta (42) specifically. |
| Cellular Localization | Type I membrane protein |
| Application Notes | IHC: Use at a concentration of 10 µg/ml. WB: Use at a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 4-5 kDa. Optimal dilutions/concentrations should be determined by the end user. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: None Constituents: 50% Glycerol, PBS. pH 7.2 |
