Application
Anti-Human_CaV1.2 - Western blot analysis of rat heart membranes: 1. Anti-Human-Cav1.2 antibody. 2. Anti-Human-Cav1.2 antibody, preincubated with the control peptide antigen.| Product Name | Cav1.2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Cav1.2This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012] |
| Immunogen | Peptide VNENTRMYIPEENHQ(C), corresponding to amino acid residues 2-15 of human Cav1.2 (exon 1B) (Accession Q13936). Intracellular, N-terminus. |
| Modification | Acetylated |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFWB |
| WB:1:500~1:1000 ICC/IF:1:100~1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CaV1.2 CACN2 CCHL1A1 CACH2 CACNA1C TS calcium channel voltage-dependent L type alpha 1C subunit CACNL1A1 LQT8 |
|---|---|
| Target | Cav1.2 |
| Molecular Weight(MW) | 240 kDa |
| Tissue Specificity | The antibody recognizes mouse CaV1.2, splice variants P22002-4 and P22002-5 of rat CaV1.2 and splice variant P15381-4 of rabbit CaV1.2. |
| SwissProt ID | Q01815 |
|---|
Application
Anti-Human_CaV1.2 - Western blot analysis of rat heart membranes: 1. Anti-Human-Cav1.2 antibody. 2. Anti-Human-Cav1.2 antibody, preincubated with the control peptide antigen.| Application Notes | WB:1:500~1:1000 ICC/IF:1:100~1:500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
