| Product Name | CD3 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [MEM - 92] to CD3T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3E may play a role in TCR-induced growth arrest, cell survival and proliferation. |
| Immunogen | Human peripheral blood lymphocytes. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | MEM-92 |
| Host Species | Mouse |
| Tested Applications | FACSIP |
| FACS: Use at an assay dependent concentration. IP: Use at an assay dependent concentration. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | T3E 186740 P09693 T3D 916 CD3-GAMMA 917 CD3GAMMA TCRE P20963 186830 186780 P04234 CD3ZETA CD3H CD3Q CD3E CD3 CD3-DELTA TCRZ 919 CD3Z CD3G 915 CD3-ZETA 186790 T3G CD3D P07766 CD3DELTA CD3 ZETA CD3 GAMMA CD3 DELTA |
|---|---|
| Target | CD3 |
| Tissue Specificity | The antibody recognizes epsilon chain of CD3 complex. |
| Cellular Localization | Type I membrane protein. |
| Application Notes | FACS: Use at an assay dependent concentration. IP: Use at an assay dependent concentration. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4 °C for 6 months. Do not freeze. |
| Storage Buffer | Phosphate buffered saline pH 7.4 containing 15mM sodium azide |
