| Product Name | Human CD3E Recombinant protein |
|---|---|
| Species Reactivity | Human |
| Gene Symbol | CD3E |
| Gene Synonyms | T3E TCRE IMD18 CD3epsilon |
| Gene Full Name | CD3 epsilon subunit of T-cell receptor complex |
| Gene Summary | The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. |
