Monoclonal Antibody to CD36 Purified AntibodyThe protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Immunogen
Platelets.
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
TR9
Host Species
Mouse
Tested Applications
FACS
FACS:1:200~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity
Human
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
The antibody TR9 cross-blocks binding of FITC-labeled standard antibody OKM5.CD36 is cell adhesion molecule in platelet adhesion and aggregation, platelet-monocyte and platelet-tumor cell interaction. CD36 is expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes. Anti-CD36 antibodies inhibit adhesive functions (e.g. adherence of infected erythrocytes to target cells).
Application
Application
Surface staining of human platelets with anti-CD36 (TR9) FITC .
Application Notes
FACS:1:200~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Storage Buffer
20 mM Tris/HCl with 15 mM sodium azide, approx. pH 7.4