| Product Name | DcR1 antibody (Functional Grade) |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Functional Grade Mouse Monoclonal antibody [TRAIL-R3-02] to DcR1TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5). Entrez Gene: 8p22-p21 |
| Immunogen | DcR1 (aa 1-280) - hIgGhc fusion protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | TRAIL-R3-02 |
| Host Species | Mouse |
| Tested Applications | FACS |
| Optimal dilutions should be determined experimentally by the researcher.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DCR1 LIT TRAILR3 TRID |
|---|---|
| Target | DcR1 |
| Tissue Specificity | The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils. |
| Application Notes | Optimal dilutions should be determined experimentally by the researcher.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 2-8°C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Storage Buffer | Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized. |
Data sheet for OM249531