Application
Immunohistochemistry of DR4 in human spleen tissue with DR4 antibody at 5 μg/mL.Application
Immunocytochemical staining of DR4 in Jurkat cells with DR4 antibody at 10μg/ml.Application
Western blot analysis of DR4 in HeLa cell lysate with DR4 antibody at 1μg/ml.| Product Name | DR4 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to DR4Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1and Fas. A novel cell death receptor was recently identified and designated DR4 (for death receptor4)(1). The ligand for this novel death receptor has been identified and termed TRAIL (2,3), which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1)(4). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4mediates apoptosis and NF-kB activation in many tissues and cells. |
| Immunogen | Synthetic peptide, corresponding to amino acids 427-445 of Human DR4. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHC-PWB |
| WB: 0.5 μg/ml. ICC/IF:10 μg/ml and IHC-P: 5 μg/ml.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Gene Synonyms | MGC9365 TRAILR1 APO2 TNFRSF10A 603611 8797 O00220 DR4 TRAILR-1 CD261 TRAILR 1 |
|---|
Application
Immunohistochemistry of DR4 in human spleen tissue with DR4 antibody at 5 μg/mL.
Application
Immunocytochemical staining of DR4 in Jurkat cells with DR4 antibody at 10μg/ml.
Application
Western blot analysis of DR4 in HeLa cell lysate with DR4 antibody at 1μg/ml.| Application Notes | WB: 0.5 μg/ml. ICC/IF:10 μg/ml and IHC-P: 5 μg/ml.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. |
| Storage Buffer | PBS with 0.02% sodium azide |
