Application
Immunohistochemistry staining of TNFRSF10A in small intestinenp_042998.1 tissue using TNFRSF10A monoclonal Antibody.| Product Name | TNFRSF10A Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TNFRSF10A, APO2, CD261, DR4, TRAIL-R1, TRAILR-1, TRAILR1, TRAIL receptor 1, CD261 antigen, Cytotoxic TRAIL receptor, Death receptor 4 |
| Product description | Cells undergo programmed cell death (Apoptosis) in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL (2,3), which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-κB activation in many tissues and cells. Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4)1. The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-κB activation in many tissues and cells. |
| Immunogen | TNFRSF10A monoclonal antibody was raised against a peptide corresponding to amino acid 2 to 21 of human DR4. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| IHC-P (5 ug/ml), WB (1 - 3 ug/ml): |
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| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | TNFRSF10A |
|---|---|
| Alternative Names | TNFRSF10A APO2 CD261 DR4 TRAIL-R1 TRAILR-1 TRAILR1 TRAIL receptor 1 CD261 antigen Cytotoxic TRAIL receptor Death receptor 4 |
| Tissue Specificity | In HeLa, a 57 kD band should be observed. |
Application
Immunohistochemistry staining of TNFRSF10A in small intestinenp_042998.1 tissue using TNFRSF10A monoclonal Antibody.| Application Notes | IHC-P (5 ug/ml), WB (1 - 3 ug/ml): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store TNFRSF10A antibody at 4 ˚C, Avoid Freezing |
| Storage Buffer | PBS containing 0.2% gelatin, 0.05% sodium azide. |
