| Product Name | E-Cadherin antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [21E9] to E-CadherinThis gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008] |
| Immunogen | human recombinant E-Cadherin protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 21E9 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| WB(1:100-1000)|IHC(1:200-400): |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | cadherin 1 type 1 E-cadherin (epithelial) Arc-1 CDHE UVO CD324 CDH1 ECAD LCAM |
|---|---|
| Target | E-Cadherin |
| Tissue Specificity | This antibody recognizes human E-Cadherin in western blot and Elisa. |
| Application Notes | WB(1:100-1000)|IHC(1:200-400): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
