| Product Name | Fibrinogen antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [40F11] to FibrinogenFibrinogen is the main protein of blood coagulation system. It is a large protein (MW 340 kDa) and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1-16 amino acids) and B (1-17 amino acids) are released by thrombin from the N-terminal parts of alpha- and beta-chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. |
| Immunogen | Fibrin degradation products |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 40F11 |
| Host Species | Mouse |
| Tested Applications | ELISAWB |
| ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 104 kDa. Can be paired for ELISA with GTX10066 Mouse monoclonal [1F3] to Fibrinogen . Optimal dilutions/concentrations should be determined by the end user.: |
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| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Synonyms | FGA 2275 MGC23614 602790 134830 MGC119423 MGC120405 SLIM2 MGC104327 105200 P02675 Fibrinogen MGC8696 MGC119425 FHL3 MGC19547 Q13643 2244 2243 Fib2 FGB P02671 MGC119422 |
|---|---|
| Target | Fibrinogen |
| Tissue Specificity | Fibrinogen, fibrin degradation products |
| Cellular Localization | Secreted |
| Application Notes | ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 104 kDa. Can be paired for ELISA with GTX10066 Mouse monoclonal [1F3] to Fibrinogen . Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | Phosphate-buffered saline, pH 7.2, containing 0.1% sodium azide |
