Mouse monoclonal antibody [2G3] to IL6Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
Immunogen
Recombinant protein expressed in E.coli corresponding to amino acids 29-212 of human IL-6
Key Feature
Clonality
Monoclonal
Isotype
IgM
Clone Number
2G3
Host Species
Mouse
Tested Applications
WB
ICC/IF (1:100):
Species Reactivity
Human
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
HSF BSF2 HGF IL-6 IL6 IFNB2 IL 6
Target
IL6
Tissue Specificity
is specific for amino acids 29-212 of human IL-6
Application
Application
IL-6 antibody (2G3) at 1:2000 + recombinant human IL-6
Application Notes
ICC/IF (1:100):
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4°C or aliquot into working amounts and store at -20°C. For long-term storage, store at -70°C (aliquotted). Avoid repeated freeze-thaw cycles.