Mouse monoclonal antibody [6D4] to MICA/MICBMICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Key Feature
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
6D4
Host Species
Mouse
Tested Applications
FACSIHC-FIPFunctional Assay
Immunohistology - Frozen: Max Dilution 1/100 Optimal dilution / concentration should be determined by the end user.:
Species Reactivity
Human
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
PERB11.1 MICA MIC-A
Target
MICA/MICB
Tissue Specificity
This antibody recognizes nonclassical MHC class I chain A (MICA) and nonclassical MHC class I chain MICB (MICB).
Application Notes
Immunohistology - Frozen: Max Dilution 1/100 Optimal dilution / concentration should be determined by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Store at -20°C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.