| Product Name | Presenilin 1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [34-4C3] to Presenilin 1The PSEN1 gene encodes a protein called Presenilin 1. This protein is involved in the development of the central nervous system and neuron survival Mutations in Presenilin 1 gene are the most common cause of early-onset Alzheimer disease and account for almost 70 percent of cases. These mutations result in increased production of the longer form of amyloid beta since Presenilins are thought to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP. |
| Immunogen | The I3 loop of the M2 receptor fusion protein (residues 225-359) was expressed as a GST fusion protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 34-4C3 |
| Host Species | Mouse |
| Tested Applications | IHC-F |
| For IHC: Use at 1-3 µg/mL: |
|
| Species Reactivity | HumanMouseMonkeyRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein A |
| Gene Synonyms | AD3 FAD PS1 S182 presenilin 1 |
|---|---|
| Target | Presenilin 1 |
| Application Notes | For IHC: Use at 1-3 µg/mL: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
