| Product Name | Amyloid-Beta 11 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Amyloid-Beta 11-pyrE, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, A4 |
| Product description | Pyroglutamic acid truncated amyloid beta 11-40/42 may have a greater propensity to aggregate under physiological conditions. In addition, this pyrE modification has been implicated as the molecular species responsible for seeding larger oligomers of amyloid-β. Pyroglutamic acid truncated amyloid beta 11-40/42’s exact involvement in the pathophysiology of Alzheimer’s disease has not been established1) Schilling S, Lauber T, Schaupp M, Manhart S, Scheel E, Bohm G, Demuth HU. On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry. 2006 Oct 17;45(41):12393-9 |
| Immunogen | A synthetic peptide corresponding to the N-terminus 11-pyro E start point. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| ELISA , Western (immuno) blotting (in testing), Immunostaining (in testing): |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | APP |
|---|---|
| Alternative Names | Amyloid-Beta 11-pyrE AAA AD1 PN2 ABPP APPI CVAP ABETA PN-II CTFgamma A4 |
| Application Notes | ELISA , Western (immuno) blotting (in testing), Immunostaining (in testing): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
