Application
Western blot analysis of lysed extracts from mouse brain tissue using APP (Phospho-668).| Product Name | APP (phospho 668) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, Nrage, AAA |
| Product description | APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.1) Hung, A. Y. and Selkoe, D. J. (1994) EMBO J. 13, 534-542. Suzuki, T. et al. (1994) EMBO J. 13, 1114-1122Ando, K. et al. (1999) J. Neurosci. 19, 4421-4427. Iijima, K. I. et al. (2000) J. Neurochem. 75, 1085-1091 |
| Immunogen | APP (Phospho-668) antibody was raised against a peptide sequence around phosphorylation site of threonine 668 (A-V-T (p) -P-E) derived from Human APP. |
| Modification | p-668 |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | APP |
|---|---|
| Alternative Names | AAA AD1 PN2 ABPP APPI CVAP ABETA PN-II CTFgamma Nrage AAA |
| Molecular Weight(MW) | 100 - 140 kDa |
| Tissue Specificity | This antibody detects endogenous level of APP only when phosphorylated at threonine 668. |
| Entrez Gene | 351 |
|---|---|
| Protein Accession | NP_000475.1 |
Application
Western blot analysis of lysed extracts from mouse brain tissue using APP (Phospho-668).| Application Notes | Western Blot: 1:500~1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
