| Product Name | Amyloid-Beta 3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Amyloid-Beta 3-pyr E, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, A4 |
| Product description | Pyro-glutamic acid truncated amyloid beta 3-40/42 may have a greater propensity to aggregate under physiological conditions. In addition, this pyro E modification has been implicated as the molecular species responsible for seeding larger oligomers of amyloid-β. Pyro-glutamic acid truncated amyloid beta 3-40/42’s exact involvement in the pathophysiology of Alzheimer’s disease has not been established.1) Schilling S, Lauber T, Schaupp M, Manhart S, Scheel E, Bohm G, Demuth HU. On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry. 2006 Oct 17;45(41):12393-9 |
| Immunogen | A synthetic peptide corresponding to the N-terminus 3-pyro E start point. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| ELISA , Western (immuno) blotting (in testing), Immunostaining (in testing): |
|
| Species Reactivity | BovineHumanSheep |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | APP |
|---|---|
| Alternative Names | Amyloid-Beta 3-pyr E AAA AD1 PN2 ABPP APPI CVAP ABETA PN-II CTFgamma A4 |
| Tissue Specificity | Will not react to rodentia. |
| Application Notes | ELISA , Western (immuno) blotting (in testing), Immunostaining (in testing): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
