Application
Detection of human MMAC/PTEN protein in Jurkat whole cell lysate using GeneTex MMAC/PTEN polyclonal antiserum| Product Name | PTEN antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse polyclonal antiserum to human MMAC / PTENMMAC/PTEN (phosphatase and tensin homolog deleted on chromosome ten) mutated in multiple advanced tumors) encodes a 54 kDa protein which acts as a dual specificity phosphatase and is capable of dephosphorylating both phospho-Ser/Thr and phospho-Tyr proteins. MMAC/PTEN was initially characterized as a tumor suppressor gene in Cowden syndrome (CS) and has since been found to be defective in many other human cancers. Recently, MMAC/PTEN also has been shown to have phosphoinositide 3- phosphatase activity that dephosphorylates phosphotidylinositol 3, 4, 5-triphosphate in vivo. Therefore, MMAC/PTEN exerts its tumor suppressor activity by being an antagonist of the PI3 kinase and a negative regulator of this pathway. |
| Immunogen | Amino acids 1-349 of human MMAC/PTEN expressed in E. coli. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Mouse |
| Tested Applications | WB |
| Optimal dilutions/concentrations should be determined by the researcher.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | 10q23del BZS DEC GLM2 MGC11227 MHAM MMAC1 PTEN1 TEP1 |
|---|
Application
Detection of human MMAC/PTEN protein in Jurkat whole cell lysate using GeneTex MMAC/PTEN polyclonal antiserum| Application Notes | Optimal dilutions/concentrations should be determined by the researcher.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Phosphate-buffered saline, pH 7.4, containing no preservatives |
