Application
Immunohistochemistry staining of IGF1 Receptor in prostate tissue using IGF1 Receptor monoclonal Antibody.| Product Name | IGF1 Receptor Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IGF1R, CD221 antigen, CD221, IGF1 Receptor, IGFR, IGF-I receptor, Soluble IGF1R variant 1, Soluble IGF1R variant 2, Type 1 IGF receptor, IGFIR, JTK13 |
| Product description | Recognises human CD221, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Clone Recognises an epitope in the alpha subunits of CD221, demonstrated by Western blotting.CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. Clone 1H7 is reported to partically block binding of IGF-I and IGF-II to CD221. Serotec recommend the use of MCA2344EL for this purpose. Immunohistology: This product requires protein digestion or heat with sodium citrate buffer pre-treatment of paraffin sections. |
| Immunogen | Human |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | FACSIHCWB |
| IGF1 Receptor antibody can be used in immunohistochemistry starting at 10 μg/mL, and flow cytometry.: |
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| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | IGF1R |
|---|---|
| Alternative Names | IGF1R CD221 antigen CD221 IGF1 Receptor IGFR IGF-I receptor Soluble IGF1R variant 1 Soluble IGF1R variant 2 Type 1 IGF receptor IGFIR JTK13 |
| Tissue Specificity | Recognizes human CD221, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Recognizes an epitope in the al ... |
Application
Immunohistochemistry staining of IGF1 Receptor in prostate tissue using IGF1 Receptor monoclonal Antibody.| Application Notes | IGF1 Receptor antibody can be used in immunohistochemistry starting at 10 μg/mL, and flow cytometry.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store IGF1 Receptor antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, pH 7.4, 0.09% sodium azide. |
