Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.1) Yamamoto Y., Sakamoto M., Fujii G., Tsuiji H., Kenetaka K., Asaka M., Hirohashi S. Hepatology 37:528-533 (2003) McClanahan T., Koseoglu S., Smith K., Grein J., Gustafson E., Black S., Kirschmeier P., Samatar A. A. Cancer Biol. Ther. 5:419-426 (2006) Becker L., Huang Q., Mashimo H. Scientific World Journal 8:1168-1176 (2008)
Immunogen
LGR5 (GPR49) antibody was raised against a peptide sequence around aa.490~494 (K-I-S-N-Q) derived from Human LGR5 (GPR49).