Application
Immunohistochemistry staining of NR0B1 in testis tissue using NR0B1 Antibody.| Product Name | NR0B1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NR0B1, AHX, AHC, AHCH, DAX1, DSS, DAX 1, DAX-1, Adrenal hypoplasia congenita, Dosage-sensitive sex reversal, GTD, HHG, Nuclear hormone receptor, NROB1, Nuclear receptor DAX-1, SRXY2, Nuclear receptor DAX1, Dax-1 receptor |
| Product description | DAX-1 (DSS-AHC critical region on the X chromosome, gene 1) is an orphan NRO Knirps-Like nuclear receptor that is involved in adrenal gland and gonad development. DAX-1 has been shown to negatively regulate transcription of the nuclear receptor steroidogenic factor 1 (SF-1). DAX-1 is also involved in the development and differentiation of anterior pituitary cells and in steroidogenesis. In the nucleus, DAX-1 binds to a retinoic acid-responsive element (RARE) and acts as a dominant-negative regulator of retinoic acid receptor-mediated transcription. DAX-1 gene transcription is regulated by Ad4BP/SF-1 (NR5A1) and is suppressed by androgens and the androgen receptor (AR/NR3C4); AR down-regulated DAX-1 gene transcription is mediated by Ad4BP/SF-1 in the presence of the ligand. Recently it has been shown that DAX-1 is required for testis development (Meeks et al. 2003). Mutations in the human DAX-1 gene lead to X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Recently two isoforms of DAX-1 has been identified. |
| Immunogen | NR0B1 antibody was raised against a peptide located in the N-Terminal domain of NR0B1 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHC |
| NR0B1 antibody can be used in immunohistochemistry starting at 13 μg/mL.: |
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| Species Reactivity | ChimpanzeeGibbonGorillaHumanOrangutan |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NR0B1 |
|---|---|
| Alternative Names | NR0B1 AHX AHC AHCH DAX1 DSS DAX 1 DAX-1 Adrenal hypoplasia congenita Dosage-sensitive sex reversal GTD HHG Nuclear hormone receptor NROB1 Nuclear receptor DAX-1 SRXY2 Nuclear receptor DAX1 Dax-1 receptor |
| Tissue Specificity | BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Application
Immunohistochemistry staining of NR0B1 in testis tissue using NR0B1 Antibody.| Application Notes | NR0B1 antibody can be used in immunohistochemistry starting at 13 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | NR0B1 antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.1% sodium azide. |
