This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Alternative Names
ARAP MDK Midkine MK MK1 NEGF2
Molecular Weight(MW)
16 kDa
Cellular Localization
Secreted
Application
WB
Western blot analysis of Midkine expression in Midkine Recombinant
protein.
IHC
Immunohistochemical analysis of paraffin-embedded human liver
carcinoma, using Midkine Antibody .