IHC
Immunohistochemistry of paraffin-embedded human liver tissue using A2M Antibody at dilution of 1:100.ICC/IF
Immunofluorescent analysis of HepG2 cells using A2M Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).| Product Name | Rabbit anti-A2M Polyclonal antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Recombinant Human Alpha-2-macroglobulin protein (1216-1467AA). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHC |
| IHC:1:20-1:200 ICC/IF:1:50-1:200 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | A2M |
|---|---|
| Gene Synonyms | A2MD CPAMD5 FWP007 S863-7 |
| Gene Full Name | beta-secretase 2 |
| Gene Summary | The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016] |
| Alternative Names | A2m antibody A2MG_HUMAN antibody Alpha 2 M antibody Alpha 2M antibody Alpha-2-M antibody Alpha-2-macroglobulin antibody C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody CPAMD5 antibody DKFZp779B086 antibody FWP007 antibody S863 7 antibody |
| Cellular Localization | Secreted. |
IHC
Immunohistochemistry of paraffin-embedded human liver tissue using A2M Antibody at dilution of 1:100.
ICC/IF
Immunofluorescent analysis of HepG2 cells using A2M Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).| Application Notes | IHC:1:20-1:200 ICC/IF:1:50-1:200 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Storage Buffer | Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
