Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing distal myopathy. [provided by RefSeq, May 2022]
Alternative Names
beta myosin heavy chain beta-myosin heavy chain cardiac muscle myosin heavy chain 7 beta cardiac myosin heavy chain 5 myHC-beta myhc-slow myosin 7 myosin heavy chain myosin heavy chain 7 myosin heavy chain beta-subunit myosin heavy chain MYH7 muscle filament myosin heavy chain polypeptide 7 cardiac muscle fetal myosin heavy chain cardiac muscle fetal myosin heavy chain polypeptide 7 myosin heavy chain 7 cardiac muscle beta myosin heavy polypeptide 7 cardiac muscle beta rhabdomyosarcoma antigen MU-RMS-40.7A sarcomeric protein