This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Alternative Names
3' 5'-cyclic AMP phosphodiesterase cAMP phosphodiesterase cAMP specific cAMP-specific 3' 5'-cyclic phosphodiesterase 4B cAMP-specific phosphodiesterase 4B DKFZp686F2182 DPDE4 dunce-like phosphodiesterase E4 MGC126529 MGC93193 OTTHUMP00000046896 PDE4B5 phosphodiesterase 4B cAMP specific Phosphodiesterase 4B cAMP-specific (dunce phosphodiesterase 4B cAMP-specific (phosphodiesterase E4 dunce homolog Drosophila) phosphodiesterase type 4B5 RP5-876C12.1 similar to Pde4b3