| Gene Symbol |
PRKN
|
| Gene Synonyms |
PDJ AR-JP LPRS2 PARK2 |
| Gene Full Name |
parkin RBR E3 ubiquitin protein ligase |
| Gene Summary |
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008] |
| Alternative Names |
AR JP antibody
E3 ubiquitin ligase antibody
E3 ubiquitin protein ligase parkin antibody
E3 ubiquitin-protein ligase parkin antibody
FRA6E antibody
LPRS 2 antibody
LPRS2 antibody
PARK 2 antibody
Park2 antibody
Parkin 2 antibody
Parkinson disease (autosomal recessive juvenile) 2 antibody
Parkinson disease (autosomal recessive juvenile) 2 parkin antibody
Parkinson disease protein 2 antibody
Parkinson juvenile disease protein 2 antibody
Parkinson protein 2 E3 ubiquitin protein ligase antibody
Parkinson protein 2 E3 ubiquitin protein ligase (parkin) antibody
PDJ antibody
PRKN 2 antibody
PRKN antibody
PRKN2 antibody
PRKN2_HUMAN antibody
Ubiquitin E3 ligase PRKN antibody |
| Molecular Weight(MW) |
52 kDa |
| Cellular Localization |
Cell projection,Cytoplasm,Endoplasmic reticulum,Membrane,Mitochondrion,Mitochondrion outer membrane,Nucleus,Synapse. |