| Gene Symbol |
EGLN1
|
| Gene Synonyms |
HPH2 PHD2 SM20 ECYT3 HALAH HPH-2 HIFPH2 ZMYND6 C1orf12 HIF-PH2 |
| Gene Full Name |
egl-9 family hypoxia inducible factor 1 |
| Gene Summary |
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009] |
| Alternative Names |
C1ORF12 antibody
Chromosome 1 Open Reading Frame 12 antibody
DKFZp761F179 antibody
ECYT 3 antibody
ECYT3 antibody
Egl 9 family hypoxia inducible factor 1 antibody
EGL 9 homolog of C. elegans 1 antibody
EGL nine (C.elegans) homolog 1 antibody
Egl nine homolog 1 (C. elegans) antibody
Egl nine homolog 1 antibody
Egl nine like protein 1 antibody
EGLN 1 antibody
Egln1 antibody
EGLN1_HUMAN antibody
HIF PH2 antibody
HIF Prolyl Hydroxylase 2 antibody
HIF-PH2 antibody
HIF-prolyl hydroxylase 2 antibody
HIFP4H 2 antibody
HIFPH2 antibody
HPH 2 antibody
HPH-2 antibody
HPH2 antibody
Hypoxia inducible factor prolyl hydroxylase 2 antibody
Hypoxia-inducible factor prolyl hydroxylase 2 antibody
ORF13 antibody
P4H2 antibody
PHD 2 antibody
PhD2 antibody
PNAS 118 antibody
PNAS 137 antibody
Prolyl Hydroxylase Domain Containing Protein 2 antibody
Prolyl hydroxylase domain-containing protein 2 antibody
Rat Homolog of SM20 antibody
SM 20 antibody
SM-20 antibody
SM20 antibody
Zinc finger MYND domain containing protein 6 antibody
ZMYND6 antibody |
| Molecular Weight(MW) |
46 kDa |
| Cellular Localization |
Cytoplasm,Nucleus. |