Western blot analysis using IRF3 antibody against A431(1), COS-7(2), MCF-7(3)cell lysate.
Immunohistochemical analysis of paraffin-embedded lung cancer tissues using IRF3 antibody with DAB staining.
Immunofluorescence analysis of HepG2 cells using IRF3 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020]
Molecular Weight(MW)
47 KDa
Source
Rabbit
Cellular Localization
Cytoplasm, Mitochondrion, Nucleus
Application
WB
Western blot analysis using IRF3 antibody against A431(1), COS-7(2), MCF-7(3)cell lysate.
IHC
Immunohistochemical analysis of paraffin-embedded lung cancer tissues using IRF3 antibody with DAB staining.
ICC/IF
Immunofluorescence analysis of HepG2 cells using IRF3 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
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