Western blot analysis using PDX1 antibody against A431(1), COS-7(2), MCF-7(3) cell lysate.
Immunofluorescence analysis of A549 cells using PDX1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Aug 2017]
Molecular Weight(MW)
31 kDa
Cellular Localization
Cytoplasm, Nucleus
Application
WB
Western blot analysis using PDX1 antibody against A431(1), COS-7(2), MCF-7(3) cell lysate.
ICC/IF
Immunofluorescence analysis of A549 cells using PDX1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes
WB:1:200-1:2000 ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage Instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05% sodium azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.
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