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BAD Antibody

Catalog Number：OM272167

  • Immunohistochemical staining of rat thymus using Bad at 2 μg/mL.

  • Immunofluorescence of BAD in Rat Thymus cells with BAD antibody at 10 μg/mL.

  • Western blot analysis of Bad in T24 cell lysates with Bad antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.

Product Profile

Product Name BAD Antibody
Antibody Type Primary Antibodies
Product description 
BAD Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain containing pro-apoptotic proteins, such as Bax, Bid, and Bik, form a growing subclass of the Bcl-2 family. Another such protein is the Bcl-2-antagonist of cell death (Bad). Bad regulates apoptosis by forming heterodimers with anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby preventing them from binding with Bax. Bad activity is regulated by its phosphorylation; it is inactivated by kinases such as Akt and MAP kinase and thus promotes cell survival, whereas JNK-induced phosphorylation promotes the apoptotic role of Bad.1) Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.
Immunogen 
Bad antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human Bad. The immunogen is located within amino acids 90 - 140 of BAD.

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

ELISAIFIHC-PWB
Bad antibody can be used for detection of Bad by Western blot at 0.5 to 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 10 μg/mL.:
Species Reactivity

HumanMouseRat
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol BAD
Alternative Names
BAD Antibody: BBC2
BCL2L8
BBC6
Bcl2 antagonist of cell death
Bcl-2-binding component 6
BAD
Sequence Similarities 2) Cat. No. 1471 - Rat Thymus Tissue Lysate

Database Links

Entrez Gene 572
Protein Accession Q92934

Application

  • Application

    Immunohistochemical staining of rat thymus using Bad at 2 μg/mL.

  • Application

    Immunofluorescence of BAD in Rat Thymus cells with BAD antibody at 10 μg/mL.

  • Application

    Western blot analysis of Bad in T24 cell lysates with Bad antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.

Positive Control 1) Cat. No. 1213 - T24 Cell Lysate
Application Notes
Bad antibody can be used for detection of Bad by Western blot at 0.5 to 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 10 μg/mL.:

Additional Information

Form Liquid
Storage Instructions BAD antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer BAD Antibody is supplied in PBS containing 0.02% sodium azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM272167
  • Price: $336.00
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  • Lead time: 4~6 Week

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