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FADD Antibody

Catalog Number：OM278425

  • Western blot analysis in WiDr cell line lysates (35ug/lane).

Product Profile

Product Name FADD Antibody
Antibody Type Primary Antibodies
Product description 
The protein encoded by this gene is an adaptor molecule
that interacts with various cell surface receptors and mediates
cell apoptotic signals. Through its C-terminal death domain, this
protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis
factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it
participates in the death signaling initiated by these receptors.
Interaction of this protein with the receptors unmasks the
N-terminal effector domain of this protein, which allows it to
recruit caspase-8, and thereby activate the cysteine protease
cascade. Knockout studies in mice also suggest the importance of
this protein in early T cell development.1) Hindryckx, P., et al. J. Immunol. 185(10):6306-6316(2010)
Immunogen 
This FADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD.

Key Feature

Clonality Polyclonal
Isotype Ig
Host Species Rabbit
Tested Applications

WB
For WB starting dilution is: 1:1000:
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol FADD
Alternative Names
FAS-associated death domain protein
FAS-associating death domain-containing protein
Growth-inhibiting gene 3 protein
Mediator of receptor induced toxicity
Protein FADD
FADD
MORT1
Molecular Weight(MW) 23 kDa

Database Links

Entrez Gene 8772
Protein Accession Q13158

Application

  • Application

    Western blot analysis in WiDr cell line lysates (35ug/lane).

Application Notes
For WB starting dilution is: 1:1000:

Additional Information

Form Liquid
Storage Instructions Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer Supplied in PBS with 0.09% (W/V) sodium azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM278425
  • Price: $336.00
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  • Store: Out of stock
  • Lead time: 4~6 Week

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