0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: HT1080 cell lysate
Product Name | Rabbit anti-MYC polyclonal antibody - N-terminal region |
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Antibody Type | Tags Antibodies |
Immunogen | The immunogen for anti-MYC antibody: synthetic peptide directed towards the N terminal of human MYC |
Clonality | Polyclonal |
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Isotype | IgG |
Host Species | Rabbit |
Tested Applications | |
Species Reactivity | |
Concentration | 1 mg/ml |
Purification | Affinity purified |
Gene Symbol | MYC |
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Gene Synonyms | c-Myc MRTL bHLHe39 |
Gene Full Name | V-myc myelocytomatosis viral oncogene homolog (avian) |
Gene Summary | MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Alternative Names | c-Myc MRTL bHLHe39 |
Molecular Weight(MW) | 50kDa |
Sequence | 454 amino acids |
Entrez Gene | 4609 |
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SwissProt ID | P01106-2 |
Protein Accession | NP_002458 |
0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: HT1080 cell lysate
Form | Liquid |
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Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
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