SMAD7 Antibody

Product Profile

Product Name	SMAD7 Antibody
Antibody Type	Primary Antibodies
Product description	Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition.1) Komuro, A., et al., (2004) Oncogene 23 (41), 6914-6923.
Immunogen	Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SMAD7.

Key Feature

Clonality	Polyclonal
Host Species	Rabbit
Tested Applications	ELISAWB
	SMAD7 antibody can be used for detection of SMAD7 by ELISA at 1:12500. SMAD7 antibody can be used for detection of SMAD7 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.:
Species Reactivity	Human
Concentration	1 mg/ml
Purification	Affinity purified

Target Information

Gene Symbol	SMAD7
Alternative Names	SMAD7 CRCS3 MADH7 MADH8
Molecular Weight(MW)	46 kDa

Database Links

Entrez Gene	4092
Protein Accession	NP_005895

Application

Positive Control	1) Cat. No. 1302 - Human Lung Tissue Lysate
Application Notes	SMAD7 antibody can be used for detection of SMAD7 by ELISA at 1:12500. SMAD7 antibody can be used for detection of SMAD7 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.:

Additional Information

Form	Liquid
Storage Instructions	For short periods of storage (days) store at 4˚C. For longer periods of storage, store SMAD7 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Storage Buffer	Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.

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• Data sheet for OM291680