| Product Name | Diablo antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to SmacSecond mitochondrial activator of caspases or Smac / Diablo can promote apoptosis by relieving the inhibition of caspases by the IAPs (1&2). The other mitochondrial activator of apoptosis is cytochrome c (1). Smac / Diablo export from the mitochondria into the cytosol can be triggered by cytotoxic drugs, DNA damage, and the ligation of FAS (CD95) death receptor (3). Once in the cytosol Smac / Diablo eliminates the inhibitory effects of the IAPs through and amino terminal interaction with the IAP proteins, and thus allow the activation of caspases (2&4). The interaction of Smac / Diablo's amino terminus with the IAP proteins has been localized to their BIR domains, for XIAP the key domain is BIR3 (4&5). |
| Immunogen | Synthetic peptide mapping to the carboxy terminal of human Smac / Diablo |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| For Western Blotting, use at a dilution of 1:200 Optimal dilutions should be determined by the user.: |
|
| Species Reactivity | Human |
| Concentration | 0.2mg/ml |
| Gene Synonyms | SMAC Q9NR28 56616 FLJ10537 605219 DIABLO-S Diablo DIABLOS SMAC3 FLJ25049 DIABLO S |
|---|---|
| Target | Diablo |
| Positive Control | HL-60 lysate. |
|---|---|
| Application Notes | For Western Blotting, use at a dilution of 1:200 Optimal dilutions should be determined by the user.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store this product at 4 °C, do not freeze. The product is stable for one year from the date of shipment. |
| Storage Buffer | Preservative: 0.1% Sodium Azide; Constituents: 0.2% Gelatin, PBS |
