| Product Name | Granzyme B antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [O2C5 / F5] to Granzyme BThe Lytic enzymes of cytotoxic lymphocytes seem to be contained within lysosome-like granules found in the cytoplasm. These granules contain perforin, a membrane pore-forming protein, and a family of serine proteases (granzymes). Granzyme B, a 32 kDa protein, is a serine Aspase associated with the granules of Natural Killer (NK) cells. Granzyme B seems to be able to elicit cell death, perhaps by activating an endogenous pathway of programmed cell death. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | O2C5/F5 |
| Host Species | Mouse |
| Tested Applications | IPWB |
| IP: Use at a concentration of 1 μg/ml. WB: Use at a concentration of 1 μg/ml. It is not recommended for immunohistochemical procedures. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Gene Synonyms | Granzyme B CCPI CGL1 3002 GZMB CTSGL1 CGL-1 CSP-B P10144 123910 CTLA1 CSPB SECT HLP CGL 1 CSP B |
|---|---|
| Target | Granzyme B |
| Tissue Specificity | The antibody detects 32 kDa human Granzyme B and 30 kDa of rat Granzyme B. It does not bind to Granzyme H, Granzyme A, or mouse Granzyme B. |
| Cellular Localization | Cytoplasmic granules of cytolytic T-Lymphocytes |
| Application Notes | IP: Use at a concentration of 1 μg/ml. WB: Use at a concentration of 1 μg/ml. It is not recommended for immunohistochemical procedures. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS with 1 mg/ml BSA, 1.5 mM sodium azide and 50% glycerol |
