Application
Antibody used in WB on Human Heart at 0.2-1 ug/ml.Application
Antibody used in IHC on Mouse hippo campus at 1:100.| Product Name | APP Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, PN-II |
| Product description | APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.1) Locascio, J.J., (2008) Arch. Neurol. 65 (6), 776-785. |
| Immunogen | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human APP. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| APP antibody can be used for detection of APP by ELISA at 1:1562500. APP antibody can be used for detection of APP by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | APP |
|---|---|
| Alternative Names | APP AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN2 PN-II |
| Molecular Weight(MW) | 85 kDa |
Application
Antibody used in WB on Human Heart at 0.2-1 ug/ml.
Application
Antibody used in IHC on Mouse hippo campus at 1:100.| Positive Control | 1) Cat. No. 1219 - MCF7 Cell Lysate |
|---|---|
| Application Notes | APP antibody can be used for detection of APP by ELISA at 1:1562500. APP antibody can be used for detection of APP by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
| Form | Liquid |
|---|---|
| Storage Instructions | For short periods of storage (days) store at 4˚C. For longer periods of storage, store APP antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
| Storage Buffer | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
