Application
Immunohistochemistry staining of NCOA3 in kidney tissue using NCOA3 monoclonal Antibody.| Product Name | NCOA3 Antibody [AC3] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | AIB1-AC3 recognizes AIB1, a member of the SRC-1 family of nuclear receptor coactivators with an apparent molecular weight of 160 kDa. The AIB1 gene has been mapped to region 20q12 and has been shown to be amplified in breast tumors and pancreatic cancer cell lines. AIB1 interacts in a ligand-dependent fashion with the estrogen receptor to enhance estrogen-dependent transcriptional gene activation. The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. |
| Immunogen | NCOA3 monoclonal antibody was raised against a synthetic peptide to the C-Terminal end of NCOA3 (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| NCOA3 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | NCOA3 |
|---|---|
| Alternative Names | NCOA3 ACTR AIB1 BHLHe42 CAGH16 CBP-interacting protein CTG26 AIB-1 P/CIP TNRC14 TRAM-1 Nuclear receptor coactivator 3 PCIP RAC-3 SRC3 TNRC16 KAT13B NCoA-3 SRC-3 |
Application
Immunohistochemistry staining of NCOA3 in kidney tissue using NCOA3 monoclonal Antibody.| Application Notes | NCOA3 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL. |
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| Form | Liquid |
|---|---|
| Storage Instructions | Store NCOA3 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, pH 7.4. |
