All products Antibodies Anti-Smad2 antibody

Anti-Smad2 antibody

Catalog Number：OM641775

  • Immunohistochemical analysis of paraffin-embedded lung cancer tissues using Smad2 antibody with DAB staining.

  • Immunofluorescence analysis of SK-OV-3 cells using Smad2 antibody(green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Product Profile

Product Name Anti-Smad2 antibody
Antibody Type Primary Antibodies
Immunogen 
Polypeptide

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

ELISAICC/IFIHC
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species Reactivity

HumanMouseRat
Concentration 1 mg/ml
Purification Protein A

Target Information

Gene Symbol SMAD2
Gene Synonyms
JV18
MADH2
MADR2
JV18-1
hMAD-2
hSMAD2
Gene Full Name SMAD family member 2
Gene Summary
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Source Rabbit
Cellular Localization Cytoplasm. Nucleus.

Application

  • IHC

    Immunohistochemical analysis of paraffin-embedded lung cancer tissues using Smad2 antibody with DAB staining.

  • ICC/IF

    Immunofluorescence analysis of SK-OV-3 cells using Smad2 antibody(green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes
IHC:1:200-1:1000
ICC/IF:1:100-1:500

Additional Information

Form Liquid
Storage Instructions Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer Purified antibody in PBS with 0.05% sodium azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM641775
  • Price: $336.00
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  • Store: Out of stock
  • Lead time: 4~6 Week

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