All products Antibodies Anti-Smad4 antibody

Anti-Smad4 antibody

Catalog Number：OM642103

  • Immunofluorescence analysis of HEK293 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

  • Immunofluorescence analysis of A549 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Product Profile

Product Name Anti-Smad4 antibody
Antibody Type Primary Antibodies
Immunogen 
Polypeptide

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

ELISAICC/IF
ICC/IF:1:100-1:500
Species Reactivity

HumanMouseRat
Concentration 1 mg/ml
Purification Protein A

Target Information

Gene Symbol SMAD4
Gene Synonyms
JIP
DPC4
MADH4
MYHRS
Gene Full Name SMAD family member 4
Gene Summary
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]
Source Rabbit
Cellular Localization Cytoplasm, Nucleus

Application

  • ICC/IF

    Immunofluorescence analysis of HEK293 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

  • ICC/IF

    Immunofluorescence analysis of A549 cells using Smad4 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes
ICC/IF:1:100-1:500

Additional Information

Form Liquid
Storage Instructions Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer Purified antibody in PBS with 0.05% sodium azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM642103
  • Price: $336.00
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  • Lead time: 4~6 Week

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