Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. As a member of the Krüppel C2H2-type zinc-finger protein family, ZFHX2 (zinc finger homeobox 2) is a 862 amino acid protein containing six C2H2-type zinc fingers. Localized to the nucleus, ZFHX2 is thought to be involved in transcriptional regulation. The gene encoding ZFHX2 maps to chromosome 14, which contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14;19) translocations found in a variety of B cell malignancies.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFIHCELISA
recommended for detection of ZFHX2 of human and canine origin by WB, IP, IF, IHC(P) and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
raised against ZFHX2 of human origin
Tissue Specificity
raised against ZFHX2 of human origin
Application
Application
Western blot analysis of ZFHX2 expression in Jurkat whole cell lysate.
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining.
Application Notes
recommended for detection of ZFHX2 of human and canine origin by WB, IP, IF, IHC(P) and ELISA
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.