| Product Name | Bcl-B Antibody (V-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Members of the Bcl-2 family of proteins regulate cell survival by either inhibiting apoptosis or by facilitating the complicated process of cell death. Bcl-B, also known as BCL2L10, Diva, Boo or BCLB, is a widely expressed 194 amino acid member of the Bcl-2 protein family. Localized to the nuclear membrane, Bcl-B promotes cell survival by suppressing BAX-induced apoptosis. Bcl-2 contains a BH4 domain as well as a transmembrane domain, both of which are necessary for its antiapoptotic effects. Overexpression of Bcl-B is thought to prevent the release of cytochrome C from the mitochondria, thereby triggering caspase-3 activation and suppressing cell apoptosis. Bcl-B is implicated in the pathogenesis of cervical cancer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBELISA |
| recommended for detection of Bcl-B of rat origin by WB and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of Bcl-B of rat origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of Bcl-B of rat origin |
| Entrez Gene | 10017 |
|---|
| Application Notes | recommended for detection of Bcl-B of rat origin by WB and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Data sheet for OM204205