Mouse monoclonal antibody [4E2] to CD3 epsilonThe protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Immunogen
The immunogen corresponding to CD3E expressed in E. Coli.
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
4E2
Host Species
Mouse
Tested Applications
ELISAFACSWB
ELISA: 1/10000.:
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Gene Synonyms
CD3E TCRE T3E
Target
CD3 epsilon
Molecular Weight(MW)
23 kDa (note)
Application
Application
Western blot analysis using CD3E mAb against Jurkat (1) cell lysate.
Application
Flow cytometric analysis of Jurkat cells using CD3E mAb (green) and negative control (purple).
Application Notes
ELISA: 1/10000.:
Additional Information
Form
Liquid
Storage Instructions
Store at 4℃, for long term storage, store at -20℃.