All products Antibodies Rabbit anti-SMAD2 polyclonal antibody - N-terminal region

Rabbit anti-SMAD2 polyclonal antibody - N-terminal region

Catalog Number：OM105589

  • at and mouse brain

  • 0.2-1 ug/ml
    ELISA Titer: 1:2500
    Positive Control: Jurkat cell lysate

Product Profile

Product Name Rabbit anti-SMAD2 polyclonal antibody - N-terminal region
Antibody Type Primary Antibodies
Immunogen 
The immunogen for anti-SMAD2 antibody: synthetic peptide directed towards the N terminal of human SMAD2

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WBIHC
WB:1:500~1:2000
IHC:1:50~1:200
Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity

BovineDogGuinea PigHorseHumanMousePigRabbitRat
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol SMAD2
Gene Synonyms
JV18
JV18-1
MADH2
MADR2
MGC22139
MGC34440
hMAD-2
hSMAD2
Gene Full Name SMAD family member 2
Gene Summary
SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD2 mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, SMAD2 is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed.
Alternative Names
JV18
JV18-1
MADH2
MADR2
MGC22139
MGC34440
hMAD-2
hSMAD2
Molecular Weight(MW) 52kDa
Sequence 467 amino acids

Database Links

Entrez Gene 4087
SwissProt ID Q15796
Protein Accession NP_005892

Application

  • Immunohistochemical

    at and mouse brain

  • Western blot

    0.2-1 ug/ml
    ELISA Titer: 1:2500
    Positive Control: Jurkat cell lysate

Application Notes
WB:1:500~1:2000
IHC:1:50~1:200
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM105589
  • Price: $336.00
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  • Lead time: 2~3 Week

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